Villa San Carlo Borromeo has a rich history. In the 8th century BC at this place was a Celtic settlement, with Julius Caesar - the outpost of the Romans. They erected powerful fortifications that remained impregnable for a long time. Subsequently, the Longobards took possession of the fortress, until finally in the XIV century this land did not cede to the Visconti family. By their order a beautiful renaissance palace was built.

The Borromeo family first appeared in the history of the villa at the end of the 17th century in connection with a dynastic marriage: Federico Borromeo married Veronica Visconti. Federico decided to rebuild the estate. The case of the father continued the son of Gilberto. He also ordered a new setting for the villa. In turn, his son was Saint Carlo Borromeo, the most famous representative of the glorious family. Borromeo owned the villa until the middle of the XX century. The aristocrats had extensive contacts. For example, in the XVIII-XIX centuries, Diderot and Stendal were frequent guests in the villa.

During the Second World War, the building and the park were very badly damaged and were in disrepair for a long time. In 1983, the estate was bought by the Italian organization Università internazionale del secondo rinascimento, which found funds for restoration work. The interiors were restored, focusing on archival drawings. The situation picked up a multi-temporal, mostly antiques. Now the villa is used both as a hotel and as a small private museum. Celebrations are also organized here.